[Coagulation Indexes and Their Prognostic Significance in Patients with Multiple Myeloma]

Abstract

Objective: To analyze the relationship between coagulation indexes and prognosis of patients with multiple myeloma (MM).

Methods: A total of 99 newly diagnosed MM patients treated in Gansu Provincial Hospital from October 2017 to October 2019 were enrolled. Plasma thromboplastin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D), platelet (PLT), and other laboratory indexes were detected. The relationship between coagulation indexes and clinical characteristics of MM patients was analyzed. The differences in survival rates among MM patients with different levels of coagulation indexes were compared, and the effect of each clinical index on the prognosis of MM patients was analyzed by univariate and multivariate.

Results: Each coagulation index was correlated to sex, disease classification and stage, and β₂-MG level of MM patients. Disease stage and β₂-MG level were positively correlated with coagulation indexes, which means that patients with late-stage disease or high β₂-MG, IgA and IgG levels were more likely to develop into coagulation disorders (P<0.05). The survival rate of patients with MM exhibiting elevated PT, FIB, and D-D levels was significantly lower (P<0.05). Univariate and multivariate analysis showed that each coagulation index was the influencing factor on the follow-up outcomes of MM patients, in which FIB was an independent prognostic factor.

Conclusion: Coagulation function is correlated with multiple clinical indicators of patients with MM and plays an important role in their prognosis.