Scandium calix[ n]arenes (n = 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies

Dalton Trans. 2021 Jun 22;50(24):8302-8306. doi: 10.1039/d1dt01330k.

Abstract

Interaction of [Sc(OR)3] (R = iPr or triflate) with p-tert-butylcalix[n]arenes, where n = 4, 6, or 8, affords a number of intriguing structural motifs, which are relatively non-toxic (cytotoxicity evaluated against cell lines HCT116 and HT-29) and a number were capable of the ring opening polymerization (ROP) of cyclohexene oxide.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / toxicity
  • Calixarenes / chemistry*
  • Calixarenes / pharmacology
  • Calixarenes / toxicity
  • Cell Survival / drug effects
  • HCT116 Cells
  • HT29 Cells
  • Humans
  • Models, Molecular
  • Polymerization
  • Scandium / chemistry*
  • Scandium / pharmacology
  • Scandium / toxicity

Substances

  • Antineoplastic Agents
  • Calixarenes
  • Scandium