Abstract
Biomolecular condensates that form via phase separation are increasingly regarded as coordinators of cellular reactions that regulate a wide variety of biological phenomena. Mounting evidence suggests that multiple steps of the RNA life cycle are organized within RNA-binding protein-rich condensates. In this Review, we discuss recent insights into the influence of phase separation on RNA biology, which has implications for basic cell biology, the pathogenesis of human diseases and the development of novel therapies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Cell Nucleus / chemistry
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Cell Nucleus / physiology
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Cytoplasm / chemistry
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Cytoplasm / physiology
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Humans
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Intrinsically Disordered Proteins / chemistry
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Mammals / metabolism
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Neoplasm Proteins / chemistry
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Neoplasms / metabolism
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Neurodegenerative Diseases / metabolism
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Osmolar Concentration
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Phase Transition
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Protein Aggregation, Pathological / prevention & control
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Protein Conformation
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Protein Domains
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Protein Isoforms / chemistry
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Protein Processing, Post-Translational
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RNA / chemistry*
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RNA / metabolism
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RNA Splicing
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RNA, Neoplasm / metabolism
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RNA-Binding Proteins / chemistry*
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Ribonucleoproteins / chemistry*
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Structure-Activity Relationship
Substances
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Intrinsically Disordered Proteins
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Neoplasm Proteins
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Protein Isoforms
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RNA, Neoplasm
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RNA-Binding Proteins
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Ribonucleoproteins
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RNA