Thermo-/pH-responsive preservative delivery based on TEMPO cellulose nanofiber/cationic copolymer hydrogel film in fruit packaging

Hiba Shaghaleh; Yousef Alhaj Hamoud; Xu Xu; He Liu; Shifa Wang; Mohamed Sheteiwy; Fuhao Dong; Lizhen Guo; Yuehan Qian; Pengfei Li; Shuangsheng Zhang

doi:10.1016/j.ijbiomac.2021.05.208

Thermo-/pH-responsive preservative delivery based on TEMPO cellulose nanofiber/cationic copolymer hydrogel film in fruit packaging

Int J Biol Macromol. 2021 Jul 31:183:1911-1924. doi: 10.1016/j.ijbiomac.2021.05.208. Epub 2021 Jun 6.

Authors

Hiba Shaghaleh¹, Yousef Alhaj Hamoud², Xu Xu³, He Liu⁴, Shifa Wang⁵, Mohamed Sheteiwy⁶, Fuhao Dong⁷, Lizhen Guo⁷, Yuehan Qian⁷, Pengfei Li⁸, Shuangsheng Zhang⁷

Affiliations

¹ College of Chemical Engineering, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University, Nanjing 210037, China; Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing 210042, China.
² College of Agricultural Science and Engineering, Hohai University, Nanjing 210098, China.
³ College of Chemical Engineering, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University, Nanjing 210037, China. Electronic address: xuxu200121@hotmail.com.
⁴ Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing 210042, China. Electronic address: liuhe.caf@gmail.com.
⁵ College of Chemical Engineering, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University, Nanjing 210037, China. Electronic address: wsfyyq@njfu.com.cn.
⁶ Department of Agronomy, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt; Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Science, Nanjing 210014, China.
⁷ College of Chemical Engineering, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University, Nanjing 210037, China.
⁸ Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi University for Nationalities, Nanning 530006, China.

PMID: 34097955
DOI: 10.1016/j.ijbiomac.2021.05.208

Abstract

Hydrogels have great potential in food packaging. However, stimuli-responsive preservative delivery-based hydrogels for emerging active packaging have not yet been explored. Herein, Unprecedented pH/temperature-responsive hydrogel films for emerging active climacteric fruit packaging were developed based on TEMPO-oxidized nanofibrillated cellulose (TOCNFs) from wheat straw with food-grade cationic-modified poly(N-isopropyl acrylamide-co-acrylamide) (CP_NIPAM-AM). TOCNF incorporation into CP_NIPAM-AM revealed desirable enhancement of characterization, antimicrobial properties, and pH/thermal-responsive behaviour. In-vitro delivery and release mechanism studies with natamycin revealed the fastest release rates in preferred low pH media, up to 32.1 times higher than that under neutral conditions via anomalous diffusion. Applying a thermal stimulus increased natamycin release rates, providing 1.5-21% gradual-additional pulses by Fickian diffusion. The final hydrogel film showed efficient decay control in response to stimuli of the climacteric fruit environment with safe, recyclable, and feasible application demonstrating the significant potential to be used as an alternative-sustainable material for stimuli-triggered preservative delivery in climacteric fruit packaging.

Keywords: Carboxyl-nanofibrillated cellulose; Climacteric fruit; Emerging active packaging; Natamycin release mechanism; Poly(N-isopropyl acrylamide-co-acrylamide); Stimuli-responsive delivery.

MeSH terms

Anti-Infective Agents / chemistry*
Antioxidants / chemistry*
Cyclic N-Oxides / chemistry*
Food Packaging
Hot Temperature
Hydrogen-Ion Concentration
Methylgalactosides / chemistry*
Nanofibers
Triticum / chemistry

Substances

Anti-Infective Agents
Antioxidants
Cyclic N-Oxides
Methylgalactosides
hydrogel film
TEMPO