Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms

Caroline Coradi Tonon; Shoaib Ashraf; José Quílez Alburquerque; Alessandra Nara de Souza Rastelli; Tayyaba Hasan; Alan M Lyons; Alexander Greer

doi:10.1111/php.13461

Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms

Photochem Photobiol. 2021 Nov;97(6):1266-1277. doi: 10.1111/php.13461. Epub 2021 Jul 8.

Authors

Caroline Coradi Tonon¹, Shoaib Ashraf¹, José Quílez Alburquerque^{1

2}, Alessandra Nara de Souza Rastelli^{1

3}, Tayyaba Hasan^{1

4}, Alan M Lyons^{5

6

7}, Alexander Greer^{6

7

8}

Affiliations

¹ Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
² Department of Organic Chemistry, Faculty of Chemistry, Complutense University of Madrid (UCM), Madrid, Spain.
³ Department of Restorative Dentistry, School of Dentistry, São Paulo State University-UNESP, Araraquara, SP, Brazil.
⁴ Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA.
⁵ Department of Chemistry, College of Staten Island, City University of New York, Staten Island, NY, USA.
⁶ Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, USA.
⁷ SingletO2 Therapeutics LLC, New York, NY, USA.
⁸ Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, NY, USA.

Abstract

This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents* / pharmacology
Biofilms
Hydrophobic and Hydrophilic Interactions
Photochemotherapy*
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use
Reactive Oxygen Species

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Photosensitizing Agents
Reactive Oxygen Species

Grants and funding

R44 DE026083/DE/NIDCR NIH HHS/United States