Abstract
In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.
Keywords:
Arabidopsis; GAPDH; hydrogen sulfide; persulfidated cysteine; posttranslational modification; stress.
Publication types
-
Research Support, Non-U.S. Gov't
-
Comment
MeSH terms
-
Animals
-
Autophagy
-
Cysteine / metabolism
-
Hydrogen Sulfide* / metabolism
-
Mammals / metabolism
-
Protein Processing, Post-Translational
-
Signal Transduction
-
Sulfides / metabolism
Substances
-
Sulfides
-
Cysteine
-
Hydrogen Sulfide
Grants and funding
This work was supported in part by the European Regional Development Fund through the Agencia Estatal de Investigación (grant no. PID2019-109785GB-I00); Junta de Andalucía (grant nos. P18-RT-3154 and US-1255781); and the Marie Skłodowska-Curie Grant Agreement (grant no. 834120 to A.A.).