Persulfidation is the mechanism underlying sulfide-signaling of autophagy

Autophagy. 2022 Mar;18(3):695-697. doi: 10.1080/15548627.2021.1936357. Epub 2021 Jun 7.

Abstract

In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.

Keywords: Arabidopsis; GAPDH; hydrogen sulfide; persulfidated cysteine; posttranslational modification; stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Autophagy
  • Cysteine / metabolism
  • Hydrogen Sulfide* / metabolism
  • Mammals / metabolism
  • Protein Processing, Post-Translational
  • Signal Transduction
  • Sulfides / metabolism

Substances

  • Sulfides
  • Cysteine
  • Hydrogen Sulfide

Grants and funding

This work was supported in part by the European Regional Development Fund through the Agencia Estatal de Investigación (grant no. PID2019-109785GB-I00); Junta de Andalucía (grant nos. P18-RT-3154 and US-1255781); and the Marie Skłodowska-Curie Grant Agreement (grant no. 834120 to A.A.).