Copper-Catalyzed Three-Component Alkene Carbofunctionalization: C-N, C-O, and C-C Bond Formation from a Single Reaction Platform

Org Lett. 2021 Jun 18;23(12):4538-4542. doi: 10.1021/acs.orglett.1c01180. Epub 2021 Jun 7.

Abstract

A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of γ-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Carbon / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Lactams / chemistry*
  • Molecular Structure

Substances

  • Alkenes
  • Lactams
  • Carbon
  • Copper