HOMA indices as screening tests for cystic fibrosis-related diabetes

J Cyst Fibros. 2022 Jan;21(1):123-128. doi: 10.1016/j.jcf.2021.05.010. Epub 2021 Jun 3.

Abstract

Background: We assessed the diagnostic performances of homeostasis model assessment indices (HOMA) of β-cell function (HOMA-%β) and of insulin resistance (HOMA-IR) for cystic fibrosis related diabetes (CFRD) screening.

Methods: Data were collected from a prospective cohort of 228 patients with CF (117 adults and 111 children). Fasting insulin and glucose levels were measured to calculate HOMA-%β and HOMA-IR. HOMA-%β <100 indicated insulin secretion deficiency and HOMA-IR >1 insulin resistance. Both were used to calculate sensitivity, specificity, and positive and negative predictive values (PPV and NPV). Two-hour oral glucose tolerance tests (2h-OGTT) defined CFRD. Analyses were conducted separately for children and adults. Performances of HOMA-%β and HOMA-IR were calculated at inclusion, for each year of follow-up and for pooled data over the follow-up period.

Results: Sensitivity, specificity, NPV and PPV were respectively: 88%, 45%, 98% and 11% for HOMA-%β and 42%, 48%, 91% and 6% for HOMA-IR in the pooled data of children; and 83%, 18%, 90% and 10% for HOMA-%β, and 39%, 80%, 92% and 18% for HOMA-IR in the pooled data of adults. Combining HOMA-%β and HOMA-IR did not improve performances.

Conclusion: Within both age groups, HOMA-%β <100 provided good sensitivity and NPV. HOMA-IR >1 had low sensitivity. Calculation of the HOMA-%β could be an interesting first-line screening approach to exclude CFRD and thus avoid unnecessary OGTT in patients for whom value is ≥100. However, HOMA-%β<100 does not support the diagnosis of CFRD and should be complemented by OGTT.

Keywords: CFRD; Cystic fibrosis; Diabetes; HOMA; Homeostasis; Indice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Child
  • Cohort Studies
  • Cystic Fibrosis / complications*
  • Diabetes Mellitus / diagnosis*
  • Female
  • Glucose Tolerance Test*
  • Humans
  • Insulin / blood*
  • Insulin Resistance
  • Insulin-Secreting Cells / metabolism*
  • Male
  • Predictive Value of Tests
  • Prospective Studies
  • Young Adult

Substances

  • Biomarkers
  • Blood Glucose
  • Insulin