Continuous renal replacement therapy in sepsis-associated acute kidney injury: Effects on inflammatory mediators and coagulation function

Abstract

Background: To explore the effect of continuous renal replacement therapy (CRRT) in patients with sepsis-associated acute kidney injury (SA-AKI) with the Acute Kidney Injury Network Classification III and its effect on inflammatory mediators and coagulation function.

Methods: We evaluated 90 patients who were diagnosed with sepsis and treated at our hospital. Forty patients received CRRT (group A) and the remainder received routine therapy (group B). We compared the renal function indices, represented by blood urea nitrogen (BUN) and serum creatinine (Scr), the urinary levels of kidney injury molecule 1, and the curative effect indices between the two groups. The incidence of major adverse cardiovascular events was compared between both groups. Further, the therapeutic effect (total effective rate) was evaluated and compared.

Results: After treatment, the levels of BUN and Scr in group A were significantly lower than those in group B (p < 0.05). Intensive care unit stay time was shorter in group A than in group B (p < 0.05). Further, the levels of the inflammatory factors C-reactive protein, tumor necrosis factor-α, interleukin 9, and interferon γ were lower in group A than in group B (p < 0.05). Lastly, the incidence of major adverse cardiovascular events was lower in group A than in group B, and the total effective rate was higher in group A than in group B (p < 0.05).

Conclusion: In patients with SA-AKI, CRRT has a better therapeutic effect than routine therapy, which is worthy of clinical promotion.

Keywords: Coagulation function; Continuous renal replacement therapy; Inflammatory factors; Sepsis; Therapeutic effect.