Water-Drinking Test in Central Serous Chorioretinopathy

Abhilash Goud; Niroj Kumar Sahoo; Mohammed Abdul Rasheed; Sumit Randhir Singh; Samatha Ankireddy; Kiran Kumar Vupparaboina; Marco Lupidi; Jay Chhablani

doi:10.4103/JOCO.JOCO_225_20

Water-Drinking Test in Central Serous Chorioretinopathy

J Curr Ophthalmol. 2021 Mar 26;33(1):62-67. doi: 10.4103/JOCO.JOCO_225_20. eCollection 2021 Jan-Mar.

Authors

Abhilash Goud¹, Niroj Kumar Sahoo¹, Mohammed Abdul Rasheed¹, Sumit Randhir Singh¹, Samatha Ankireddy², Kiran Kumar Vupparaboina³, Marco Lupidi⁴, Jay Chhablani^{1

5}

Affiliations

¹ Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
² Department of Ophthalmology, Kansas City School of Medicine, University of Missouri, Kansas City, MO, USA.
³ Srujana Centre for Innovation, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
⁴ Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy.
⁵ UPMC Eye Centre, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Purpose: To evaluate choroidal changes in central serous chorioretinopathy (CSCR) patients after water-drinking test (WDT).

Methods: This prospective study included treatment-naïve acute and chronic CSCR eyes and healthy controls. Intraocular pressure and optical coherence tomography measurements with choroidal vascular index (CVI) measurements were done at baseline. Patients were asked to drink 1 L of water, and tests were repeated at 15, 30, and 45 min.

Results: Fifty-six eyes from 42 patients were enrolled. Choroidal area, luminal area, and stromal area were higher at baseline in eyes with acute CSCR compared to healthy controls. Chronic CSCR eyes showed an increase in choroidal area and stromal area and a decrease in the luminal area at 15 min. There was a significant decrease in CVI at 30 and 45 min in chronic CSCR and CVI at 45 min in fellow eyes of acute CSCR. Repeated-measures analysis of variance (ANOVA) showed a significant change in central macular thickness in acute CSCR, choroidal thickness in fellow eyes of acute CSCR, stromal area, and total choroidal area in chronic CSCR. Mixed model ANOVA showed that the change in various choroidal parameters seen had no interaction with the eye type.

Conclusion: Although change in various parameters was seen in acute CSCR, chronic CSCR, and fellow eyes of acute CSCR following WDT, the change was not significantly different among the groups.

Keywords: Central serous chorioretinopathy; Choroidal vascular index; Optical coherence tomography; Water-drinking test.