Echotexture Analysis of L4 Supraspinous Enthesis in Ankylosing Spondylitis

Kuo-Lung Lai; Fang-Chuan Kuo; Chih-Wei Tseng; Hsin-Hua Chen; Yin-Yin Liao

doi:10.4103/JMU.JMU_37_20

Echotexture Analysis of L4 Supraspinous Enthesis in Ankylosing Spondylitis

J Med Ultrasound. 2020 Sep 5;29(1):32-38. doi: 10.4103/JMU.JMU_37_20. eCollection 2021 Jan-Mar.

Authors

Kuo-Lung Lai^{1

2}, Fang-Chuan Kuo³, Chih-Wei Tseng¹, Hsin-Hua Chen^{1

4}, Yin-Yin Liao⁵

Affiliations

¹ Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
³ Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan.
⁴ School of Medicine, National Yang-Ming University, Taipei, Taiwan.
⁵ Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan.

Abstract

Background: Enthesopathy is a main characteristic of ankylosing spondylitis (AS). However, ultrasonographic features of supraspinous enthesis in AS have not yet been reported.

Methods: Forty-seven AS patients and 22 healthy individuals were enrolled and completed the study. L4 supraspinous entheses were assessed through an ultrasound (US) unit with the participants in a lateral decubitus position. Entheseal echogenicity was interpreted upon inspection of the US image. An entheseal grayscale (GS) value determination, along with an echotexture analysis using a gray-level co-occurrence matrix algorithm, was performed. The thoracolumbar fascia just above the enthesis was also analyzed. An enthesis-to-fascia ratio (EFR) of each texture feature was used for the purpose of intergroup comparison.

Results: The prevalence of abnormal entheseal echogenicity in the AS and healthy groups was 19.1% and 13.6%, respectively (P = 0.42). The AS group experienced a higher GS EFR (0.56 [0.10-1.08] vs. 0.40 [0.12-0.89], P = 0.007), higher contrast EFR (0.62 [0.15-1.23] vs. 0.49 [0.23-1.33], P = 0.049), higher variance EFR (0.44 [0.06-1.21] vs. 0.35 [0.13-1.10], P = 0.023), and lower homogeneity EFR (1.07 [0.97-1.27] vs. 1.11 [1.04-1.19], P = 0.011) in comparison to the healthy group.

Conclusion: Echotexture analysis identified the subtle structural changes in L4 supraspinous enthesis in AS patients. It proved to be superior to the inspection method and may possess the potential for providing early detection of supraspinous enthesopathy in AS.

Keywords: Ankylosing spondylitis; echotexture analysis; enthesopathy; supraspinous enthesis; ultrasonography.