Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution

Catriona MacDonald; Sarah E McClelland

doi:10.1016/j.tig.2021.05.003

Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution

Trends Genet. 2021 Aug;37(8):691-694. doi: 10.1016/j.tig.2021.05.003. Epub 2021 Jun 1.

Authors

Catriona MacDonald¹, Sarah E McClelland²

Affiliations

¹ Department of Comparative Biomedical Sciences, The Royal Veterinary College, 4 Royal College St, London, NW1 0TU, UK.
² Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, EC1M 6BQ, UK. Electronic address: s.mcclelland@qmul.ac.uk.

PMID: 34083067
DOI: 10.1016/j.tig.2021.05.003

Abstract

Cancer research has recently benefitted from the integration of evolutionary theory to study somatic genome evolution during tumor development. Here, we explore how investigating mechanistic principles of chromosomal instability during both species and somatic evolution can reciprocally inform each field.

Publication types

Review

MeSH terms

Aging / genetics*
Aging / pathology
Chromosomal Instability / genetics*
Clonal Evolution / genetics*
Humans
Neoplasms / genetics