Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan

Akiyoshi Takami; Shinichiro Watanabe; Yoshikazu Yamamoto; Hiroshi Kondo; Yukiharu Bamba; Masahiko Ohata; Seiji Mishima; Hiroshi Kubota; Akihiko Nishiura; Reiko Miura; Miyuki Iwagami; Katsumi Higashi; Yutaka Yatomi; Kaoru Tohyama; Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the Japanese Association of Medical Technologists (JWG-JSLH-JAMT).

doi:10.1007/s12185-021-03166-y

Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan

Int J Hematol. 2021 Sep;114(3):373-380. doi: 10.1007/s12185-021-03166-y. Epub 2021 Jun 2.

Authors

Akiyoshi Takami¹, Shinichiro Watanabe², Yoshikazu Yamamoto³, Hiroshi Kondo⁴, Yukiharu Bamba⁵, Masahiko Ohata⁶, Seiji Mishima⁷, Hiroshi Kubota⁸, Akihiko Nishiura⁹, Reiko Miura¹⁰, Miyuki Iwagami¹¹, Katsumi Higashi¹², Yutaka Yatomi¹³, Kaoru Tohyama¹⁴; Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the Japanese Association of Medical Technologists (JWG-JSLH-JAMT).

Affiliations

¹ Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, 480-1195, Japan. takami-knz@umin.ac.jp.
² Fujisawa City Hospital, Fujisawa, Japan.
³ Tenri Health Care University, Tenri, Japan.
⁴ Kansai University of Health Sciences, Kumatori, Japan.
⁵ BML General Laboratory, BML, INC, Kawagoe, Japan.
⁶ Shizuoka Red Cross Hospital, Shizuoka, Japan.
⁷ Sanyo women's college, Hatsukaichi, Japan.
⁸ Clinical Laboratory, Osaka City University Hospital, Osaka, Japan.
⁹ Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan.
¹⁰ Sapporo Hokuyu Hospital, Sapporo, Japan.
¹¹ Tatebayashi Kosei General Hospital, Tatebayashi, Japan.
¹² Kyorin University School of Health Sciences, Kyorin, Japan.
¹³ Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
¹⁴ Kawasaki Medical School Hospital, Kurashiki, Japan.

PMID: 34080169
DOI: 10.1007/s12185-021-03166-y

Abstract

Although it is known that red blood cell (RBC) parameters and platelet count depend on ethnicity and sex, their reference intervals in healthy Asian populations are limited. The aim of this study was to establish reference intervals for RBC parameters and platelet count for healthy adults in Japan. A total of 750 healthy adults (447 women and 303 men; median age 40 years (18-67 years) at seven Japanese centers who participated in regular medical checkups entered this study. Their RBC parameters and platelet count were measured using automated hematocytometers. The reference intervals of the RBC parameters and platelet count according to sex in healthy adults were determined. There was an age-specific decrease in RBC counts and an age-specific increase in mean corpuscular volume in men. This study emphasizes the need to consider sex and age in the clinical use of reference intervals of RBC parameters.

Keywords: Mean corpuscular volume; Platelet count; Red blood cell parameters; Reference interval.

Publication types

Multicenter Study

MeSH terms

Adolescent
Adult
Aged
Biomarkers*
Erythrocyte Indices*
Female
Healthy Volunteers
Humans
Japan / epidemiology
Male
Middle Aged
Platelet Count*
Public Health Surveillance
Young Adult

Substances

Biomarkers

Grants and funding

#18K08343/Ministry of Education, Culture, Sports and Technology of Japan