Low dose contrast media in step-and-shoot coronary angiography with third-generation dual-source computed tomography: feasibility of using 30 mL of contrast media in patients with body surface area <1.7 m2

Liang Jin; Bing Jie; Yiyi Gao; An'qi Jiang; Tingwen Weng; Ming Li

doi:10.21037/qims-20-500

Low dose contrast media in step-and-shoot coronary angiography with third-generation dual-source computed tomography: feasibility of using 30 mL of contrast media in patients with body surface area <1.7 m²

Quant Imaging Med Surg. 2021 Jun;11(6):2598-2609. doi: 10.21037/qims-20-500.

Authors

Liang Jin¹, Bing Jie², Yiyi Gao¹, An'qi Jiang¹, Tingwen Weng³, Ming Li^{1

4}

Affiliations

¹ Radiology Department, Huadong Hospital, affiliated with Fudan University, Shanghai, China.
² Radiology Department, Shanghai Pulmonary Hospital, Affiliated with Tongji University, Shanghai, China.
³ Cardiology Department, Huadong Hospital, Affiliated with Fudan University, Shanghai, China.
⁴ Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China.

Abstract

Background: Reducing contrast media volume in coronary computed tomography angiography minimizes the risk of adverse events but may compromise diagnostic image quality. We aimed to evaluate coronary computed tomography angiography's diagnostic image quality while using 30 mL of contrast media in patients with a body surface area <1.7 m².

Methods: This prospective study included patients who underwent coronary computed tomography angiography from May 2018 to June 2019. The patients were divided into a low-dose group, who received 30 mL of contrast media, and a routine-dose group, who received contrast media based on body weight. Patient characteristics, coronary computed tomography angiography results, and quantitative and qualitative image results were assessed and compared.

Results: In total, 103 patients with a body surface area <1.7 m² were 53 in the low-dose group and 50 in the routine-dose group. Sex, age, body surface area, body weight, and heart rate were similar between the groups (P>0.05). A contrast media volume of 30±0 mL was used for the low-dose group, and 41.62±4.59 mL was used for the routine-dose group. The low-dose group's computed tomography values were significantly different from those of the routine-dose group (P<0.05). The radiologists demonstrated agreement regarding diagnostic image quality and accuracy (kappa =0.91 and 0.85, respectively).

Conclusions: Using 30 mL of contrast media for coronary computed tomography angiography in patients with a body surface area <1.7 m² provided a suitable diagnostic image quality for coronary artery disease diagnosis. Although radiation doses were similar between the groups, the decreased contrast media volume was likely beneficial for the patients.

Keywords: Contrast media; body surface area; computed tomography angiography; coronary angiography; coronary artery disease.