Lenvatinib Plus Camrelizumab versus Lenvatinib Monotherapy as Post-Progression Treatment for Advanced Hepatocellular Carcinoma: A Short-Term Prognostic Study

Fuqun Wei; Qizhen Huang; Jian He; Liuping Luo; Yongyi Zeng

doi:10.2147/CMAR.S304820

Lenvatinib Plus Camrelizumab versus Lenvatinib Monotherapy as Post-Progression Treatment for Advanced Hepatocellular Carcinoma: A Short-Term Prognostic Study

Cancer Manag Res. 2021 May 27:13:4233-4240. doi: 10.2147/CMAR.S304820. eCollection 2021.

Authors

Fuqun Wei^#¹, Qizhen Huang^#², Jian He¹, Liuping Luo¹, Yongyi Zeng¹

Affiliations

¹ Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, People's Republic of China.
² Department of Radiation Oncology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, People's Republic of China.

^# Contributed equally.

Abstract

Objective: Compared the outcomes between lenvatinib plus camrelizumab therapy and lenvatinib monotherapy as post-progression treatment for advanced hepatocellular carcinoma (HCC) with progressive disease (PD).

Patients and methods: A total of 48 advanced HCC patients were included in this retrospective study between June 2019 and March 2020. The patients were divided into the lenvatinib plus camrelizumab group (n=21) and the lenvatinib group (n=27). Primary endpoints were overall survival (OS) and progression-free survival (PFS), and secondary endpoints were the objective response rate (ORR) and adverse events (AEs).

Results: The median follow-up time was 8.4 months. The median OS was not obtained. The median PFS of lenvatinib plus camrelizumab group was significantly longer than that of lenvatinib group (8.0 months vs 4.0 months, p=0.011). Compared with lenvatinib group, lenvatinib plus camrelizumab group had higher ORR (28.57% vs 7.41%) and disease control rate (DCR) (71.43% vs 51.85%). The most common adverse events (AEs) included hand-foot skin reaction, hypertensions and abnormal hepatic function damage. Overall, 23.81% and 25.93% of patients experienced grade ≥3AEs in the lenvatinib plus camrelizumab group and the lenvatinib group, respectively.

Conclusion: Lenvatinib plus camrelizumab as post-progression treatment is effective and safe for advanced hepatocellular carcinoma with PD.

Keywords: PD-1; advanced hepatocellular carcinoma; lenvatinib.

Grants and funding

This study was sponsored by the Fujian provincial medical center of hepatobiliary; Key Clinical Specialty Discipline Construction Program of Fuzhou, Fujian, P.R.C (201912002); Synergetic enhancement of photodynamic therapy/chemotherapy of tumor by tumor microenvironment triggered self-supplying oxygen BMSF @ Pt system (2019Y0013).