Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children

Jingying Zhou; Pan Wang; Ran Zhang; Xiaokai Huang; Hanqi Dai; Li Yuan; Jichen Ruan

doi:10.2147/PGPM.S310780

Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children

Pharmgenomics Pers Med. 2021 May 25:14:601-607. doi: 10.2147/PGPM.S310780. eCollection 2021.

Authors

Jingying Zhou¹, Pan Wang¹, Ran Zhang², Xiaokai Huang¹, Hanqi Dai¹, Li Yuan³, Jichen Ruan¹

Affiliations

¹ Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
² Sydney School of Public Health, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
³ Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, People's Republic of China.

Abstract

Background: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies.

Methods: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan.

Results: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13-2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26-7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25-2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05-6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2-3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31-2.84, P = 0.001) relative to those with 0-1 risk genotype.

Conclusion: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children.

Keywords: HMGA2; glioma; polymorphism; susceptibility.