Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp

Anna Herman; Andrzej Przemysław Herman

doi:10.3390/antibiotics10060655

Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp

Antibiotics (Basel). 2021 May 31;10(6):655. doi: 10.3390/antibiotics10060655.

Authors

Anna Herman¹, Andrzej Przemysław Herman²

Affiliations

¹ Faculty of Health Sciences, Warsaw School of Engineering and Health, Bitwy Warszawskiej 1920 18 Street, 02-366 Warsaw, Poland.
² Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, Poland.

Abstract

Clinical isolates of Candida yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant Candida sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant Candida sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described.

Keywords: antifungal drug; drug-resistant Candida sp.; herbal active constituents; herbalproducts.

Publication types

Review