Daily Lifestyle and Cutaneous Malignancies

Int J Mol Sci. 2021 May 14;22(10):5227. doi: 10.3390/ijms22105227.

Abstract

Daily lifestyle is a fundamental part of human life and its influence accumulates daily in the human body. We observe that a good daily lifestyle has a beneficial impact on our health; however, the actual effects of individual daily lifestyle factors on human skin diseases, especially skin cancers, have not been summarized. In this review, we focused on the influence of daily lifestyle on the development of skin cancer and described the detailed molecular mechanisms of the development or regulation of cutaneous malignancies. Several daily lifestyle factors, such as circadian rhythm disruption, smoking, alcohol, fatty acids, dietary fiber, obesity, and ultraviolet light, are known to be associated with the risk of cutaneous malignancies, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Although the influence of some daily lifestyles on the risk of skin cancers is controversial, this review provides us a better understanding of the relationship between daily lifestyle factors and skin cancers.

Keywords: basal cell carcinoma; daily lifestyle; melanoma; merkel cell carcinoma; skin cancer; squamous cell carcinoma.

Publication types

  • Review

MeSH terms

  • Alcohol Drinking / adverse effects
  • Carcinoma, Merkel Cell / etiology
  • Carcinoma, Squamous Cell / etiology
  • Circadian Rhythm
  • Diet*
  • Dietary Fiber / pharmacology
  • Fruit
  • Humans
  • Life Style*
  • Melanoma / etiology
  • Melanoma, Cutaneous Malignant
  • Obesity / complications
  • Risk Factors
  • Skin Neoplasms / etiology*
  • Smoking / adverse effects
  • Ultraviolet Rays / adverse effects*
  • Vegetables

Substances

  • Dietary Fiber