A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder

Soudeh Ghafouri-Fard; Elham Badrlou; Mohammad Taheri; Kenneth M Dürsteler; Annette Beatrix Brühl; Dena Sadeghi-Bahmani; Serge Brand

doi:10.3390/ijms22105156

A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder

Int J Mol Sci. 2021 May 13;22(10):5156. doi: 10.3390/ijms22105156.

Authors

Soudeh Ghafouri-Fard¹, Elham Badrlou¹, Mohammad Taheri², Kenneth M Dürsteler^{3

4}, Annette Beatrix Brühl⁵, Dena Sadeghi-Bahmani^{5

6

7}, Serge Brand^{5

6

8

9}

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
² Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
³ Psychiatric Clinics, Division of Substance Use Disorders, University of Basel, 4002 Basel, Switzerland.
⁴ Center for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8001 Zurich, Switzerland.
⁵ Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002 Basel, Switzerland.
⁶ Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran.
⁷ Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁸ Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, 4052 Basel, Switzerland.
⁹ School of Medicine, Tehran University of Medical Sciences, Tehran 25529, Iran.

Abstract

Aim: Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs).

Methods: We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.

Results: Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation.

Conclusion: Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.

Keywords: bipolar disorder; circRNA; lncRNA; miRNA.

Publication types

Review

MeSH terms

Animals
Bipolar Disorder / physiopathology*
Humans
RNA, Untranslated / genetics*

Substances

RNA, Untranslated