Synthesis, Characterizations, and 9.4 Tesla T2 MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles

Shanti Marasini; Huan Yue; Son Long Ho; Ji Ae Park; Soyeon Kim; Ki-Hye Jung; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Adibehalsadat Ghazanfari; Kwon-Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/nano11051355

Synthesis, Characterizations, and 9.4 Tesla T₂ MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles

Nanomaterials (Basel). 2021 May 20;11(5):1355. doi: 10.3390/nano11051355.

Authors

Affiliations

¹ Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea.
² Division of RI-Convergence Research, Korea Institute of Radiological and Medical Science (KIRAMS), Seoul 01817, Korea.
³ Medical Device-Bio Research Institute, Korea Testing and Research Institute, Gwacheon 13810, Korea.
⁴ Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea.
⁵ Department of Biology Education, Teacher's College, Kyungpook National University, Taegu 41566, Korea.

Abstract

Polyacrylic acid (PAA)-coated lanthanide oxide (Ln₂O₃) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T₂) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r₂ values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r₁ values were negligible at all MR fields, indicating their exclusive induction of T₂ relaxations with negligible induction of T₁ relaxations. Their effectiveness as T₂ MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T₂ MR images at a 9.4 T MR field after intravenous administration into mice tails.

Keywords: Ho2O3; MRI; Tb2O3; high MR field; nanoparticles; polyacrylic acid-coating.

Abstract

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