Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy

Int J Mol Sci. 2021 May 5;22(9):4891. doi: 10.3390/ijms22094891.

Abstract

The nematode worm Caenorhabditis elegans has been used extensively to enhance our understanding of the human neuromuscular disorder Duchenne Muscular Dystrophy (DMD). With new arising clinically relevant models, technologies and treatments, there is a need to reconcile the literature and collate the key findings associated with this model.

Keywords: C. elegans; DMD; dystrophin; muscle.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology*
  • Disease Models, Animal
  • Epistasis, Genetic
  • Humans
  • Muscular Dystrophy, Duchenne / genetics
  • Muscular Dystrophy, Duchenne / pathology*
  • Mutation / genetics
  • Phenotype