Toxicity assessment of three-component Fe-Cr-Ni biomedical materials using an augmented simplex design

Shih-Hang Chang; Bor-Yann Chen; Yung-Chih Lin

doi:10.1016/j.msec.2012.05.008

Toxicity assessment of three-component Fe-Cr-Ni biomedical materials using an augmented simplex design

Mater Sci Eng C Mater Biol Appl. 2012 Oct 1;32(7):1893-1896. doi: 10.1016/j.msec.2012.05.008. Epub 2012 May 14.

Authors

Shih-Hang Chang¹, Bor-Yann Chen², Yung-Chih Lin²

Affiliations

¹ Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan. Electronic address: shchang@niu.edu.tw.
² Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan.

PMID: 34062672
DOI: 10.1016/j.msec.2012.05.008

Abstract

This study firstly establishes the toxicity assessment of three-component Fe-Cr-Ni biomedical materials using Probit dose-response model and augmented simplex design. The individually determined toxicity rankings of these three cations is in the order Ni²⁺≥Cr³⁺>Fe³⁺. The ternary Fe-Cr-Ni system's EC₅₀ contour plot shows a hump with EC₅₀=897.5mg/L, and a saddle with EC₅₀=637.5mg/L. Ternary Fe-Cr-Ni biomedical implants may possess good biocompatibility when the chemical compositions of selectively leached metal ions approach the hump region, but present at increased toxic risk when close to the saddle region. Toxicity of Fe-Cr-Ni three-component biomedical materials with various chemical compositions can be predicted and verified economically and efficiently using an augmented simplex design.

Keywords: Augmented simplex design; Biomaterials; Probit dose–response; Toxicity assessment.