Polypropylene non-woven fabric membrane via surface modification with biomimetic phosphorylcholine in Ce(IV)/HNO3 redox system

Jie Zhao; Qiang Shi; Shifang Luan; Lingjie Song; Huawei Yang; Paola Stagnaro; Jinghua Yin

doi:10.1016/j.msec.2012.04.057

Polypropylene non-woven fabric membrane via surface modification with biomimetic phosphorylcholine in Ce(IV)/HNO₃ redox system

Mater Sci Eng C Mater Biol Appl. 2012 Oct 1;32(7):1785-1789. doi: 10.1016/j.msec.2012.04.057. Epub 2012 May 9.

Authors

Jie Zhao¹, Qiang Shi¹, Shifang Luan¹, Lingjie Song¹, Huawei Yang¹, Paola Stagnaro², Jinghua Yin³

Affiliations

¹ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
² Istituto per Io Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Via de Marini 6, 16149 Genova, Italy.
³ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: yinjh@ciac.jl.cn.

PMID: 34062656
DOI: 10.1016/j.msec.2012.04.057

Abstract

Surface modification of polypropylene non-woven fabric membrane (NWF) for improving its hemocompatibility was developed by grafting a biomimic monomer, 2-methacryloyloxyethyl phosphorycholine (MPC). The NWF membrane surface was first activated by potassium peroxydisulfate to form hydroxyl groups, and then grafted with MPC using ceric (IV) ammonium nitrate as the redox initiator. The surface chemical changes before and after modification were confirmed by Fourier transform infrared spectroscopy with an ATR unit (FTIR-ATR) and X-ray photoelectron spectroscopy (XPS); the water contact angle results showed the gradual changes in wettability from hydrophobic to hydrophilic surface. Meanwhile, the hemocompatibility of these samples was also evaluated by protein adsorption and platelet adhesion. These experimental results exhibited that the introduction of poly(MPC) onto the NWF membrane surfaces substantially improved their hemocompatibility. The feasibility and simplicity of this procedure may lead to potential applications of NWF membranes in biomedical separation and blood purification.

Keywords: 2-Methacryloyloxyethyl phosphorylcholine; Graft copolymerization; Hemocompatibility; Polypropylene non-woven fabric (NWF) membrane; Redox graft polymerization.