Balancing risk in a patient with primary bone histiocytic sarcoma during pregnancy: Case report and review of the literature

Ayman Al-Amri; Murtadha Al-Khabori; Nihal Al-Riyami; Ibrahim Al-Haddabi

doi:10.1016/j.ijscr.2021.106021

Balancing risk in a patient with primary bone histiocytic sarcoma during pregnancy: Case report and review of the literature

Int J Surg Case Rep. 2021 Jun:83:106021. doi: 10.1016/j.ijscr.2021.106021. Epub 2021 May 26.

Authors

Ayman Al-Amri¹, Murtadha Al-Khabori², Nihal Al-Riyami³, Ibrahim Al-Haddabi⁴

Affiliations

¹ Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman. Electronic address: ayman.s.alamri@gmail.com.
² Haematology Department, Sultan Qaboos University Hospital, Muscat, Oman.
³ Obstetrics & Gynaecology Department, Sultan Qaboos University Hospital, Muscat, Oman.
⁴ Pathology Department, Sultan Qaboos University Hospital, Muscat, Oman.

Abstract

Introduction and importance: Histiocytic sarcoma (HS) is a rare, aggressive malignant neoplasm of hematopoietic cell origin. Primary HS of the proximal humerus, without involvement of lymph nodes or bone marrow, or systemic features, is very rare.

Case presentation: We report a rare case of primary bony HS of the proximal humerus without bone marrow involvement in a healthy 33-year-old pregnant woman. She was successfully treated with surgical resection during pregnancy and radiotherapy post-delivery.

Clinical discussion: This is the first report of a patient with primary bony HS during pregnancy. This highlights the fact that although HS is a neoplasm of hemolymphoid cell lineage, it frequently arises in non-lymphoid organs.

Conclusion: This case emphasizes the importance of a multidisciplinary approach and the need for balancing treatment risk in a patient with primary bone HS during pregnancy.

Keywords: Histiocytic sarcoma; Pregnancy; Proximal humerus.