Development of a core outcome set for interventions to prevent stillbirth

Bobae V Kim; Edoardo C Aromataris; Philippa Middleton; Rosemary Townsend; Shakila Thangaratinam; James M N Duffy; Willem de Lint; Suzette Coat; Vicki Flenady; Asma Khalil; Ben W Mol

doi:10.1111/ajo.13369

Development of a core outcome set for interventions to prevent stillbirth

Aust N Z J Obstet Gynaecol. 2021 Oct;61(5):658-666. doi: 10.1111/ajo.13369. Epub 2021 Jun 1.

Authors

Bobae V Kim^{1

2}, Edoardo C Aromataris³, Philippa Middleton^{1

4

5

6}, Rosemary Townsend^{7

8}, Shakila Thangaratinam⁹, James M N Duffy^{10

11}, Willem de Lint¹², Suzette Coat¹, Vicki Flenady^{5

6}, Asma Khalil¹³, Ben W Mol¹⁴

Affiliations

¹ The Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia.
² Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
³ Joanna Briggs Institute, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
⁴ South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
⁵ NHMRC Stillbirth Centre of Research Excellence, Brisbane, Queensland, Australia.
⁶ Mater Medical Research Institute, South Brisbane, Queensland, Australia.
⁷ Molecular and Clinical Sciences Research Institute, St George's, University of London and St George's University Hospitals NHS Foundation Trust, London, UK.
⁸ Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
⁹ World Health Organization (WHO) Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, Birmingham, UK.
¹⁰ Balliol College, University of Oxford, Oxford, UK.
¹¹ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
¹² College of Business, Government and Law, Flinders University, Adelaide, South Australia, Australia.
¹³ Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
¹⁴ Department of Obstetrics & Gynaecology, Monash University, Melbourne, Victoria, Australia.

PMID: 34060072
DOI: 10.1111/ajo.13369

Abstract

Aims: To develop a core outcome set for trials investigating interventions to prevent stillbirth.

Materials & methods: Outcomes identified from a systematic literature review and semi-structured interviews with parents in Australia and the UK were entered into a two-round online Delphi survey and focus group/consensus meetings.

Results: A core outcome set containing 11 outcomes in two categories. Five outcomes were related to the mother; fetal loss, onset of and mode of delivery, maternal mortality or near miss, psychological and social impact on the women, women's knowledge. Six outcomes were related to the baby; timing of stillbirth, neonatal mortality, gestational age at delivery, birthweight, congenital anomaly, NICU/SCBU or other higher-level neonatal care length of stay.

Conclusions: Implementation and dissemination of this core outcome set in future trials will contribute towards coordinated outcome reporting and advancing usefulness of research to guide clinical practice.

Keywords: Core outcomes; Delphi; Stillbirth; core outcome set.

Publication types

Systematic Review

MeSH terms

Consensus
Female
Humans
Infant, Newborn
Maternal Mortality
Outcome Assessment, Health Care
Pregnancy
Prenatal Care*
Research Design
Stillbirth*

Abstract

Publication types

MeSH terms

Grants and funding