Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy

Ziyang Cao; Dongdong Li; Junxia Wang; Xianzhu Yang

doi:10.1016/j.actbio.2021.05.023

Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy

Acta Biomater. 2021 Aug:130:17-31. doi: 10.1016/j.actbio.2021.05.023. Epub 2021 May 28.

Authors

Ziyang Cao¹, Dongdong Li¹, Junxia Wang¹, Xianzhu Yang²

Affiliations

¹ Guangzhou First People's Hospital, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, and Key Laboratory of Biomedical Engineering of Guangdong Province, and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.
² Guangzhou First People's Hospital, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, and Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, Guangdong 510006, China. Electronic address: yangxz@scut.edu.cn.

PMID: 34058390
DOI: 10.1016/j.actbio.2021.05.023

Abstract

Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest in recent years. On the one hand, a high ROS level has been detected in many types of tumor cells. On the other hand, ROS generation is also induced during photodynamic, sonodynamic, or chemodynamic therapy. In addition, multiple types of polymers are sensitive to ROS. Therefore, numerous ROS-responsive polymeric nanocarriers with unique ROS-responsive characteristics have been developed. This review discusses ROS-sensitive polymeric nanocarriers to improve drug delivery efficacy. In particular, ROS-responsive nanocarriers for synergistic cancer therapy are highlighted. The development of novel ROS-sensitive nanocarriers holds great potential for combining ROS-mediated therapy, such as photodynamic therapy, and other therapies to achieve synergistic anticancer efficacy. STATEMENT OF SIGNIFICANCE: Reactive oxygen species (ROS)-responsive nanocarriers aroused widespread interest in recent years. On the one hand, a high level of ROS has been found in many types of tumor cells. On the other hand, the ROS generation can also be induced during the photodynamic, sonodynamic, or chemodynamic therapy. Besides, multiple types of polymers were sensitive to the ROS. Therefore, numerous ROS-responsive polymeric nanocarriers with unique ROS responsive characteristics have been developed. This review focuses on the ROS-sensitive polymeric nanocarriers to improve drug delivery efficacy for synergistic cancer therapy.

Keywords: Drug delivery; ROS-responsive polymer; ROS-sensitive nanocarriers; Synergistic cancer therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Line, Tumor
Drug Carriers
Nanoparticles*
Neoplasms* / drug therapy
Photochemotherapy*
Polymers
Reactive Oxygen Species

Substances

Drug Carriers
Polymers
Reactive Oxygen Species