Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum

Kelly L L Wong; Aditya Nair; George J Augustine

doi:10.3389/fncir.2021.658228

Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum

Front Neural Circuits. 2021 May 13:15:658228. doi: 10.3389/fncir.2021.658228. eCollection 2021.

Authors

Kelly L L Wong¹, Aditya Nair^{2

3}, George J Augustine^{1

2}

Affiliations

¹ Neuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
² Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
³ Computation and Neural Systems, California Institute of Technology, Pasadena, CA, United States.

Abstract

The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum-from anatomical connectivity to behavioral manipulations-to inform future analyses of claustral function.

Keywords: acetylcholine; claustrum; dopamine; neuromodulation; serotonin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Claustrum*
Dopamine
Neurons
Substantia Nigra
Ventral Tegmental Area

Substances

Dopamine