Hypothermia for Acute Spinal Cord Injury

Aditya Vedantam; Allan D Levi

doi:10.1016/j.nec.2021.03.009

Hypothermia for Acute Spinal Cord Injury

Neurosurg Clin N Am. 2021 Jul;32(3):377-387. doi: 10.1016/j.nec.2021.03.009.

Authors

Aditya Vedantam¹, Allan D Levi²

Affiliations

¹ Department of Neurological Surgery, University of Miami MILLER School of Medicine, Lois Pope Life Center, 1095 Northwest 14th Terrace, Suite 2-24, Miami, FL 33136, USA.
² Department of Neurological Surgery, University of Miami MILLER School of Medicine, Lois Pope Life Center, 1095 Northwest 14th Terrace, Suite 2-24, Miami, FL 33136, USA. Electronic address: ALevi@med.miami.edu.

PMID: 34053725
DOI: 10.1016/j.nec.2021.03.009

Abstract

Neuroprotection after acute spinal cord injury is an important strategy to limit secondary injury. Animal studies have shown that systemic hypothermia is an effective neuroprotective strategy that can be combined with other therapies. Systemic hypothermia affects several processes at the cellular level to reduce metabolic activity, oxidative stress, and apoptotic neuronal cell death. Modest systemic hypothermia has been shown to be safe and feasible in the acute phase after cervical spinal cord injury. These data have provided the impetus for an active multicenter randomized controlled trial for modest systemic hypothermia in acute cervical spinal cord injury.

Keywords: Cooling catheter; Hypothermia; Neuroprotection; Spinal cord injury; Trauma.

Publication types

Review

MeSH terms

Animals
Humans
Hypothermia, Induced*
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Spinal Cord Injuries* / therapy