Improving the Early Diagnosis of Gastric Cancer

Robert J Huang; Joo Ha Hwang

doi:10.1016/j.giec.2021.03.005

Improving the Early Diagnosis of Gastric Cancer

Gastrointest Endosc Clin N Am. 2021 Jul;31(3):503-517. doi: 10.1016/j.giec.2021.03.005.

Authors

Robert J Huang¹, Joo Ha Hwang²

Affiliations

¹ Division of Gastroenterology and Hepatology, Stanford University, 300 Pasteur Drive, Alway Building M211, Stanford, CA 94305, USA. Electronic address: rjhuang@stanford.edu.
² Division of Gastroenterology and Hepatology, Stanford University, 300 Pasteur Drive, Alway Building M211, Stanford, CA 94305, USA.

Abstract

Gastric cancer (GC) remains a leading cause of cancer morbidity and mortality worldwide. Outcomes from GC remain poor, especially in Western nations where cancer diagnosis is usually at advanced stages where curative resection is not possible. By contrast, nations of East Asia have adopted methods of population-level screening with improvements in stage of diagnosis and survival. In this review, the authors discuss the epidemiology of GC in Western populations, highlight at-risk populations who may benefit from screening, overview screening modalities, and discuss promising approaches to early GC detection.

Keywords: Cancer stage; Early detection; East Asia; Endoscopic screening; Helicobacter pylori; Intestinal metaplasia.

Publication types

Review

MeSH terms

Early Detection of Cancer
Helicobacter Infections*
Humans
Risk Factors
Stomach Neoplasms* / diagnosis
Stomach Neoplasms* / epidemiology

Grants and funding

K08 CA252635/CA/NCI NIH HHS/United States