The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions

Jiang Peng; Xin-Jie Yu; Lei-Lei Yu; Feng-Wei Tian; Jian-Xin Zhao; Hao Zhang; Wei Chen; Qi-Xiao Zhai

doi:10.1016/j.foodres.2021.110331

The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions

Food Res Int. 2021 Jun:144:110331. doi: 10.1016/j.foodres.2021.110331. Epub 2021 Mar 22.

Authors

Jiang Peng¹, Xin-Jie Yu², Lei-Lei Yu³, Feng-Wei Tian¹, Jian-Xin Zhao¹, Hao Zhang⁴, Wei Chen⁵, Qi-Xiao Zhai⁶

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
² Hwa Chong Institution (College), 661 Bukit Timah Road, Singapore.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, China.
⁵ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China.
⁶ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu, China. Electronic address: zhaiqixiao@sina.com.

PMID: 34053534
DOI: 10.1016/j.foodres.2021.110331

Abstract

The link between the gut microbiome and bone health has begun to attract widespread interest in recent years. The gut microbiome are vital in many diseases involving bone loss. Probiotics, prebiotics, and dietary supplements have been suggested to protect bone health by altering the composition of the gut microbiota. Notably, studying the relationship between the gut microbiome and bone health can provide a basis for the prevention and treatment of bone diseases. This review focuses on the link between the gut microbiome and bone diseases, exploring current knowledge of the mechanisms by which gut bacteria affect bone health. In addition, the influences of dietary supplements on the interactions between the gut microbiome and bone health are discussed. This knowledge will promote new ideas for gut microbiota-mediated dietary interventions in patients with bone diseases.

Keywords: Bone diseases; Dietary strategies; Epithelial barrier; Gut microbiome; Immune system; Probiotics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Density
Diet
Gastrointestinal Microbiome*
Humans
Prebiotics
Probiotics*

Substances

Prebiotics