Surface enhanced Raman spectroscopy (SERS) is a powerful technique for sensitive analysis which is attracting great attention in the last decades. In this review, different gold nanostructures that have been exploited for SERS analysis are described, ranging from gold nanospheres to anisotropic and complex-shaped gold nanostructures, in which the presence of high aspect ratio features leads to an increment of the electromagnetic field at the surface of the nanomaterial, resulting in enhanced SERS response. In addition to the shape of the nanostructure, the interparticle nanogaps play a prominent role in the SERS efficiency. In this sense, different approaches such as nanoaggregation and formation of assemblies and ordered structures lead to the creation of the so-called hot spots. SERS measurements may be performed in solution, while usually the nanostructures are deposited building a SERS substrate, which can be created via attachment of chemically prepared gold nanostructures, as well as via top-down physical methods. Among the classical supports for creating the SERS substrates, in the last years there is a trend towards the development of flexible supports based on polymers as well as paper. Finally, some recent applications of gold nanostructures-based SERS substrates within the analytical field are discussed to spotlight the potential of this technique in real-world analytical scenarios.
Keywords: Analytical applications; Flexible membranes; Gold nanoparticles; Gold nanostars; Gold nanostructures; Paper-based SERS; SERS; Substrate fabrication; Surface enhanced Raman spectroscopy.
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