Report of the 22nd nationwide follow-up Survey of Primary Liver Cancer in Japan (2012-2013)

Masatoshi Kudo; Namiki Izumi; Norihiro Kokudo; Michiie Sakamoto; Shuichiro Shiina; Tadatoshi Takayama; Ryosuke Tateishi; Osamu Nakashima; Takamichi Murakami; Yutaka Matsuyama; Arata Takahashi; Hiroaki Miyata; Shoji Kubo

doi:10.1111/hepr.13675

Report of the 22nd nationwide follow-up Survey of Primary Liver Cancer in Japan (2012-2013)

Hepatol Res. 2022 Jan;52(1):5-66. doi: 10.1111/hepr.13675. Epub 2022 Jan 2.

Authors

Masatoshi Kudo^{1

2}, Namiki Izumi^{1

3}, Norihiro Kokudo^{1

4}, Michiie Sakamoto^{1

5}, Shuichiro Shiina^{1

6}, Tadatoshi Takayama^{1

7}, Ryosuke Tateishi^{1

8}, Osamu Nakashima^{1

9}, Takamichi Murakami^{1

10}, Yutaka Matsuyama^{1

11}, Arata Takahashi^{1

12

13}, Hiroaki Miyata^{1

12

13}, Shoji Kubo^{1

14}

Affiliations

¹ Liver Cancer Study Group of Japan, Follow-up Survey Committee, Japan.
² Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
³ Department of Gastroenterology, Musashino Red Cross Hospital, Tokyo, Japan.
⁴ National Center for Global Health and Medicine, Tokyo, Japan.
⁵ Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
⁶ Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
⁷ Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
⁸ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁹ Department of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Japan.
¹⁰ Department of Diagnostic and Interventional Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
¹¹ Department of Biostatistics, School of Public Health, University of Tokyo, Tokyo, Japan.
¹² National Clinical Database, Tokyo, Japan.
¹³ Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
¹⁴ Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

PMID: 34050584
DOI: 10.1111/hepr.13675

Abstract

In the 22nd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 21 155 newly registered patients and 43 041 previously registered follow-up patients were compiled from 538 institutions over a 2-year period from January 1, 2012 to December 31, 2013. Basic statistics compiled for patients newly registered in the 22nd survey were cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathologic diagnosis, recurrence status and autopsy findings. Compared with the previous 21st survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, more patients with non-B non-C HCC, smaller tumor diameter and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 2002 and 2013 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter or Child-Pugh grade) and by treatment type (hepatectomy, radiofrequency ablation therapy, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2013 into five time period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer worldwide.

Keywords: combined hepatocellular cholangiocarcinoma; cumulative survival rate; hepatocellular carcinoma; intrahepatic cholangiocarcinoma; liver cancer study group of Japan; nationwide follow-up survey; nationwide survey.