Radiation-Chemical Biotechnology for Producing Ultrashort (50-100n) Single-Chain Polydeoxyribonucleotides with Anticancer Activity

S V Stovbun; A S Vedenkin; M G Mikhaleva; A A Bukhvostov; D A Kuznetsov

doi:10.1007/s10517-021-05175-7

Radiation-Chemical Biotechnology for Producing Ultrashort (50-100n) Single-Chain Polydeoxyribonucleotides with Anticancer Activity

Bull Exp Biol Med. 2021 May;171(1):74-76. doi: 10.1007/s10517-021-05175-7. Epub 2021 May 29.

Authors

S V Stovbun¹, A S Vedenkin¹, M G Mikhaleva², A A Bukhvostov^{1

3}, D A Kuznetsov^{1

3}

Affiliations

¹ N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
² N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia. wawe@bk.ru.
³ N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 34050411
DOI: 10.1007/s10517-021-05175-7

Abstract

The fundamental possibility of obtaining ultrashort (50n-100n) single-stranded polydeoxyribonucleotides by the method of radiation-chemical destruction of total yeast DNA was established and their anticancer activity was shown.

Keywords: DNA; MTT test; cytotoxicity; polydeoxyribonucleotides; radiation-chemical destruction.

MeSH terms

Biotechnology
DNA*
Polydeoxyribonucleotides*

Substances

Polydeoxyribonucleotides
DNA