ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

Insoo Hyun; Ellen Wright Clayton; Yali Cong; Misao Fujita; Steven A Goldman; Lori R Hill; Nuria Monserrat; Hiromitsu Nakauchi; Roger A Pedersen; Heather M Rooke; Jun Takahashi; Jürgen A Knoblich

doi:10.1016/j.stemcr.2021.05.005

ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

Stem Cell Reports. 2021 Jun 8;16(6):1409-1415. doi: 10.1016/j.stemcr.2021.05.005. Epub 2021 May 27.

Authors

Affiliations

¹ Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Center for Bioethics, Harvard Medical School, Boston, MA, USA. Electronic address: insoo.hyun@case.edu.
² Center for Biomedical Ethics and Society, Departments of Pediatrics and Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA; School of Law, Vanderbilt University, Nashville, TN, USA.
³ Department of Medical Ethics and Law, Peking University School of Health Humanities, Beijing, China.
⁴ Uehiro Research Division for iPS Cell Ethics, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.
⁵ University of Rochester Medical Center, Rochester, NY, USA; University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
⁶ Department of Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
⁷ Pluripotency for Organ Regeneration. Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Technology (BIST), 08028 Barcelona, Spain.
⁸ Institute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University, Stanford, CA, USA; Division of Stem Cell Therapy, Institute of Medical Science University of Tokyo, Tokyo, Japan.
⁹ Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.
¹⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹¹ Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
¹² Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Vienna, Austria.

Abstract

The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.

Keywords: ISSCR guidelines; animal research; chimeric embryos; stem cell chimeras.

Publication types

Review

MeSH terms

Animals
Chimera*
Embryo Research / ethics*
Humans
Pluripotent Stem Cells*
Practice Guidelines as Topic*
Societies, Scientific / ethics
Societies, Scientific / standards*
Stem Cell Research / ethics*
Stem Cell Transplantation / ethics
Stem Cell Transplantation / standards*