Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines

Amander T Clark; Ali Brivanlou; Jianping Fu; Kazuto Kato; Debra Mathews; Kathy K Niakan; Nicolas Rivron; Mitinori Saitou; Azim Surani; Fuchou Tang; Janet Rossant

doi:10.1016/j.stemcr.2021.05.008

Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines

Stem Cell Reports. 2021 Jun 8;16(6):1416-1424. doi: 10.1016/j.stemcr.2021.05.008. Epub 2021 May 27.

Authors

Amander T Clark¹, Ali Brivanlou², Jianping Fu³, Kazuto Kato⁴, Debra Mathews⁵, Kathy K Niakan⁶, Nicolas Rivron⁷, Mitinori Saitou⁸, Azim Surani⁹, Fuchou Tang¹⁰, Janet Rossant¹¹

Affiliations

¹ University of California, Los Angeles, CA, USA. Electronic address: clarka@ucla.edu.
² The Rockefeller University, New York, NY, USA.
³ The University of Michigan, An Arbor, MI, USA.
⁴ Osaka University, Yamadaoka, Osaka, Japan.
⁵ Johns Hopkins University, Baltimore, MD, USA.
⁶ Francis Crick Institute and The Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
⁷ Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria.
⁸ Kyoto University, Sakyo-ku, Kyoto, Japan.
⁹ The Gurdon Institute, Cambridge, UK.
¹⁰ Beijing Advanced Innovation Center for Genomics, Beijing, China.
¹¹ Gairdner Foundation, Toronto, Ontario, Canada. Electronic address: janet.rossant@gairdner.org.

Abstract

The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016. Since then, rapid progress has been made in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. Therefore, a working group of international experts was convened to review the oversight process and provide an update to the guidelines. This report captures the discussion and summarizes the major recommendations made by this working group, with a specific emphasis on updating the categories of review and engagement with the specialized scientific and ethical oversight process.

Keywords: embryo models; embryo research; gametoogensis; guidelines.

Publication types

Review

MeSH terms

Embryo Research / ethics*
Embryo, Mammalian
Embryonic Stem Cells*
Gametogenesis
Humans
Models, Biological
Practice Guidelines as Topic*
Societies, Scientific / ethics*
Societies, Scientific / standards*
Stem Cell Research / ethics*

Abstract

Publication types

MeSH terms

Grants and funding