Pathology of intraductal papillary mucinous neoplasms

Naziheh Assarzadegan; Elizabeth Thompson; Kevan Salimian; Matthias M Gaida; Lodewijk A A Brosens; Laura Wood; Syed Z Ali; Ralph H Hruban

doi:10.1007/s00423-021-02201-0

Pathology of intraductal papillary mucinous neoplasms

Langenbecks Arch Surg. 2021 Dec;406(8):2643-2655. doi: 10.1007/s00423-021-02201-0. Epub 2021 May 28.

Authors

Naziheh Assarzadegan¹, Elizabeth Thompson¹, Kevan Salimian¹, Matthias M Gaida², Lodewijk A A Brosens³, Laura Wood^{1

4}, Syed Z Ali^{1

4}, Ralph H Hruban^{5

6}

Affiliations

¹ Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA.
² Institute of Pathology, University Medical Center Mainz, Mainz, Germany.
³ Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
⁴ Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA.
⁵ Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA. rhruban@jhmi.edu.
⁶ Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21212, USA. rhruban@jhmi.edu.

Abstract

Background: Intraductal papillary mucinous neoplasms (IPMNs) represent a unique opportunity to treat and prevent a curable neoplasm before it has the chance to progress to incurable cancer. This prospect, however, has to be balanced with the real risk of over treating patients with lesions that would, in fact, never progress during the life of the patient.

Purpose: Informed clinical decisions in the treatment of IPMNs are first and foremost based on a deep understanding of the pathology of these lesions.

Conclusions: Here we review the pathology of IPMNs, with an emphasis on the clinical relevance of the important features that characterize these lesions.

Keywords: Intraductal oncocytic papillary neoplasm; Intraductal papillary mucinous neoplasm; Intraductal tubulopapillary neoplasm; Pancreas cancer; Pancreatic cancer; Pathology.

Publication types

Review

MeSH terms

Carcinoma, Pancreatic Ductal* / surgery
Humans
Pancreatic Neoplasms*

Grants and funding

T32 CA193145/CA/NCI NIH HHS/United States