Carboxylated β-cyclodextrin anchored hollow mesoporous silica enhances insecticidal activity and reduces the toxicity of indoxacarb

Liupeng Yang; Amir E Kaziem; Yigang Lin; Chao Li; Yuting Tan; Suqing Huang; Dongmei Cheng; HanHong Xu; Zhixiang Zhang

doi:10.1016/j.carbpol.2021.118150

Carboxylated β-cyclodextrin anchored hollow mesoporous silica enhances insecticidal activity and reduces the toxicity of indoxacarb

Carbohydr Polym. 2021 Aug 15:266:118150. doi: 10.1016/j.carbpol.2021.118150. Epub 2021 May 5.

Authors

Liupeng Yang¹, Amir E Kaziem², Yigang Lin¹, Chao Li¹, Yuting Tan¹, Suqing Huang³, Dongmei Cheng⁴, HanHong Xu⁵, Zhixiang Zhang⁶

Affiliations

¹ Guangdong Biological Pesticide Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, China.
² Guangdong Biological Pesticide Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, China; Department of Environmental Agricultural Science, Institute of Environmental Studies and Research, Ain Shams University, Cairo 11566, Egypt.
³ Department of Environmental Agricultural Science, Institute of Environmental Studies and Research, Ain Shams University, Cairo 11566, Egypt.
⁴ College of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
⁵ Guangdong Biological Pesticide Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, China. Electronic address: hhxu@scau.edu.cn.
⁶ Guangdong Biological Pesticide Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, China. Electronic address: zdsys@scau.edu.cn.

PMID: 34044957
DOI: 10.1016/j.carbpol.2021.118150

Abstract

In this study, a pesticide controlled release system with dual response characteristics of pH and enzyme triggering was developed. Indoxacarb (IDC) was loaded into hollow mesoporous silica (HMS) nanoparticles, carboxylated β-cyclodextrin (β-CD) acted as a capping molecule to couple with the amino-functionalized HMS, and their well-defined morphological structures were confirmed by scanning electron microscopy and transmission electron microscopy. The results showed that the prepared IDC loaded HMS-CD had high loading efficiency (26.42%, w/w) and showed excellent dual response properties to pH and the α-amylase enzyme. IDC loaded HMS-CD nanoparticles showed better insecticidal activity against Spodoptera frugiperda than applying the same dose of IDC emulsifiable concentrate, and the toxicity of IDC loaded HMS-CD to zebrafish was reduced by more than 5-fold, indicating that insecticide delivery systems based on β-CD-anchored HMS nanoparticles could potentially be applied for sustainable control of pests and reduce harm to non-target organisms and the environment.

Keywords: Hollow mesoporous silica; Indoxacarb; Spodoptera frugiperda; Zebrafish; β-Cyclodextrin.

MeSH terms

Animals
Drug Carriers / chemistry*
Drug Carriers / toxicity
Insecticides / pharmacology*
Nanoparticles / chemistry*
Nanoparticles / toxicity
Oxazines / pharmacology*
Porosity
Silicon Dioxide / chemistry*
Silicon Dioxide / toxicity
Spodoptera / drug effects
Zebrafish
beta-Cyclodextrins / chemistry*
beta-Cyclodextrins / toxicity

Substances

Drug Carriers
Insecticides
Oxazines
beta-Cyclodextrins
indoxacarb
Silicon Dioxide