PRESERVE: Randomized Trial of Intensive Versus Standard Blood Pressure Control in Small Vessel Disease

Stroke. 2021 Aug;52(8):2484-2493. doi: 10.1161/STROKEAHA.120.032054. Epub 2021 May 28.

PRESERVE Study Team:
J Birns, J Davies, A Barkat, F Cappuccio, T Robinson, L Grey, D Briley, A Bhalla, M J Hollocks, L A Davies, V C Cambridge, B Moynihan, S Tripper, A Dixit, J Davies, M Davis, G Ford, C Dafe, J McGirr, M Spillane, D Waugh, B Ellison-Handley, D Werring, A Banara

¹ Stroke Research Group, Department of Clinical Neuroscience, University of Cambridge (H.S.M., M.E., I.D.C., H.S., D.J.T.).
² Atkinson Morley Neuroscience Centre, St. Georges NHS Healthcare Trust (U.K., A.M.).
³ Leeds Teaching Hospitals NHS Trust (A.H.).
⁴ Sheffield Teaching Hospital NHS Foundation Trust (K.H.).
⁵ Department of Psychiatry, University of Cambridge (J.T.O.).
⁶ Kings College Institute of Psychiatry, Psychology and Neurosciences, London, United Kingdom (R.G.M.).
⁷ Neurosciences Research Centre, Molecular and Clinical Science Research Institute, St George's University of London, United Kingdom (T.R.B.).
⁸ Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, United Kingdom (A.M.B.).
⁹ Oxford University Hospitals NHS Foundation Trust, University of Oxford (G.A.F.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: blood pressure; clinical trial; dementia, vascular; diffusion tensor imaging; magnetic resonance imaging.