Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing

Zhongcao Wu; Hui Zhuang; Bing Ma; Yin Xiao; Bahattin Koc; Yufang Zhu; Chengtie Wu

doi:10.34133/2021/9780943

Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing

Research (Wash D C). 2021 May 7:2021:9780943. doi: 10.34133/2021/9780943. eCollection 2021.

Authors

Zhongcao Wu^{1

2

3}, Hui Zhuang^{1

2}, Bing Ma¹, Yin Xiao⁴, Bahattin Koc^{5

6

7}, Yufang Zhu^{1

2}, Chengtie Wu^{1

2}

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
² Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
³ School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China.
⁴ Institute of Health and Biomedical Innovation, Queensland University of Technology, 7 Brisbane 4059, Australia.
⁵ Integrated Manufacturing Technologies Research and Application Center, Sabanci University, Tuzla 34956 Istanbul, Turkey.
⁶ SUNUM Nanotechnology Research Center, Sabanci University, Tuzla 34956 Istanbul, Turkey.
⁷ Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla 34956 Istanbul, Turkey.

Abstract

Melanoma is a serious malignant skin tumor. Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies. To address these problems, we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (named MCSA hydrogels) for in situ photothermal ablation of melanoma followed by the wound healing process. The proposed MCSA hydrogel had controllable gelation properties, reasonable strength, and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive components. The doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared (NIR) irradiation. Moreover, the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes angiogenesis. Hence, such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing, showing great promise for melanoma therapy and tissue regeneration.