Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2128-2140. doi: 10.1161/ATVBAHA.121.316034. Epub 2021 May 27.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cardiovascular diseases; hypertriglyceridemia; lipoprotein lipase; prolyl 4-hydroxylase; triglycerides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / enzymology*
  • Aorta / pathology
  • Aortic Diseases / enzymology
  • Aortic Diseases / genetics
  • Aortic Diseases / pathology
  • Aortic Diseases / prevention & control*
  • Atherosclerosis / enzymology
  • Atherosclerosis / genetics
  • Atherosclerosis / pathology
  • Atherosclerosis / prevention & control*
  • Autoantibodies / blood
  • Diet, High-Fat
  • Disease Models, Animal
  • Gene Knockout Techniques*
  • Lipoprotein Lipase / metabolism
  • Lipoproteins, LDL / immunology
  • Lipoproteins, LDL / metabolism
  • Liver / enzymology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Plaque, Atherosclerotic*
  • Prolyl Hydroxylases / genetics*
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism
  • Transcriptome
  • Triglycerides / blood

Substances

  • Autoantibodies
  • Lipoproteins, LDL
  • Receptors, LDL
  • Triglycerides
  • oxidized low density lipoprotein
  • P4htm protein, mouse
  • Prolyl Hydroxylases
  • Lipoprotein Lipase