Human pegivirus type 1 infection in Asia-A review of the literature

Rev Med Virol. 2022 Jan;32(1):e2257. doi: 10.1002/rmv.2257. Epub 2021 May 26.

Abstract

The human pegivirus type 1 (HPgV-1)-as known as hepatitis G virus and GB virus C-is a common single-stranded RNA flavivirus. Because few studies have demonstrated an association between HPgV-1 infection and disease, screening for HPgV-1 is not performed routinely. Nonetheless, a beneficial impact of HPgV-1 infection on HIV disease progression has been reported in multiple studies. Given the burden of HIV in Asia and the complex interactions between viral co-infections and the host, we provide a comprehensive overview of the existing data from Asia on HPgV-1 infection, including the prevalence and circulating genotypes in all Asian countries with data reported. This review highlights the research conducted thus far and emphasizes the need for additional studies on HPgV-1 across the Asian continent.

Keywords: Asia; GB virus C; GBV-C; HIV; HPgV-1; genotype; hepatitis G virus; pegivirus.

Publication types

  • Review

MeSH terms

  • Asia / epidemiology
  • Coinfection* / epidemiology
  • Flaviviridae Infections* / complications
  • Flaviviridae Infections* / epidemiology
  • GB virus C* / genetics
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • Hepatitis, Viral, Human*
  • Humans
  • Phylogeny
  • RNA, Viral / genetics

Substances

  • RNA, Viral