Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis

Li Zheng; Lixia Wang; Yuan Hu; Jia Yi; Lun Wan; Yujuan Shen; Si Liu; Xiaorong Zhou; Jianping Cao

doi:10.1111/pim.12871

Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis

Parasite Immunol. 2021 Oct;43(10-11):e12871. doi: 10.1111/pim.12871. Epub 2021 Jul 21.

Authors

Li Zheng^{1

2

3}, Lixia Wang², Yuan Hu^{1

4}, Jia Yi², Lun Wan², Yujuan Shen^{1

4}, Si Liu², Xiaorong Zhou², Jianping Cao^{1

4}

Affiliations

¹ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Key Laboratory of Parasite and Vector Biology, National Health Commission of People's Republic of China, WHO Collaborating Center for Tropical Diseases, Shanghai, China.
² Hubei Provincial Center for Disease Control and Prevention, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Key Laboratory for Applied Toxicology, Wuhan, China.
³ Department of Immunology, Hainan Medical University, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Haikou, Hainan, China.
⁴ The School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Gamma-delta (γδ) T cells are the bridge between natural and adaptive immunity. In the present study, peripheral blood was collected from 13 patients with advanced schistosomiasis (schistosomiasis group) and 13 uninfected people (control group) to investigate the γδ T cells and their subtypes in human schistosomiasis. Compared with the control group, the proportion of Vδ1 cells and CD27⁺ Vδ1⁺ cells in the schistosomiasis group increased significantly, while CD27^- cells and CD27^- Vδ1^- cells decreased. Only the level of IL-17A differed between the groups, being significantly decreased in the schistosomiasis group. In the schistosomiasis group, there were no correlations between the liver fibrosis and subsets of γδ T cells, or the level of cytokines. Additionally, the level of IL-17A correlated positively with the proportion of CD27^- Vδ1^- cells. Thus, there was a higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis. The decreased IL-17A might be related to the reduction in CD27^- Vδ1^- cell.

Keywords: Schistosoma japonicum; IL-17; fibrosis; schistosomiasis; γδ T cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Humans
Liver Cirrhosis
Receptors, Antigen, T-Cell, gamma-delta*
Schistosomiasis*
T-Lymphocyte Subsets

Substances

Cytokines
Receptors, Antigen, T-Cell, gamma-delta