Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Guowei Gong; Yuzhong Zheng; Yang Yang; Yixuan Sui; Zhen Wen

doi:10.1155/2021/9952578

Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Evid Based Complement Alternat Med. 2021 May 6:2021:9952578. doi: 10.1155/2021/9952578. eCollection 2021.

Authors

Guowei Gong¹, Yuzhong Zheng², Yang Yang¹, Yixuan Sui³, Zhen Wen⁴

Affiliations

¹ Department of Bioengineering, Zunyi Medical University, Zhuhai Campus, Zhuhai, Guangdong 519041, China.
² Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou, Guangdong 521041, China.
³ Department of Neuroscience, City University of Hong Kong, Hong Kong 999077, China.
⁴ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.

Abstract

Astragalus is a popular Materia Medica in China, and it could be applied in the treatment of various diseases. It contains a variety of chemically active ingredients, such as saponins, flavonoids, and polysaccharides. Plant-derived bioactive chemicals are considered natural, safe, and beneficial. Among the infinite plant-identified and isolated molecules, flavonoids have been reported to have positive effects on human health. Calycosin is the most important active flavonoid substance identified predominantly within this medicinal plant. In recent years, calycosin has been reported to have anticancer, antioxidative, immune-modulatory, and estrogenic-like properties. This review collected recent relevant literatures on calycosin and summarized its potential pharmaceutical properties and working mechanism involved, which provided solid basis for future clinical research.

Publication types

Review