The synthesis of 2-(functionalized methyl)-1 beta-methylcarbapenems

S M Schmitt; T N Salzmann; D H Shih; B G Christensen

doi:10.7164/antibiotics.41.780

The synthesis of 2-(functionalized methyl)-1 beta-methylcarbapenems

J Antibiot (Tokyo). 1988 Jun;41(6):780-7. doi: 10.7164/antibiotics.41.780.

Authors

S M Schmitt¹, T N Salzmann, D H Shih, B G Christensen

Affiliation

¹ Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.

PMID: 3403372
DOI: 10.7164/antibiotics.41.780

Abstract

The synthesis of 1 beta-methylcarbapenems having a ROCH2 substituent at the 2-position is described. Their in vitro antibacterial activity and DHP-I susceptibilities are presented.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology
Structure-Activity Relationship
beta-Lactams

Substances

Anti-Bacterial Agents
beta-Lactams