Abstract
A chemical investigation on the EtOAc extract of the endophytic fungus Eutypella scoparia SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H (1-8), one C-28 steroid eutyscoparene A (9), one triterpenoid eutyscoparene B (10), six known terpenoids, and two known steroids. Their structures including absolute configurations were established on the basis of spectroscopic data analysis, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Compound 7 displayed antibacterial activity against S. aureus and MRSA (methicillin-resistant Staphylococcus aureus) with MIC values of 6.3 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Ascomycota / chemistry*
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Cell Line, Tumor
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China
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Phytochemicals / isolation & purification
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Phytochemicals / pharmacology
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Plant Leaves / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Staphylococcus aureus / drug effects
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Steroids / isolation & purification
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Steroids / pharmacology*
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Terpenes / isolation & purification
Substances
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Anti-Bacterial Agents
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Phytochemicals
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Sesquiterpenes
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Steroids
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Terpenes