Circulating HLA-G and its association with cardiovascular markers in pregnancy

Tove Lekva; Daniel P Jacobsen; Meryam Sugulle; Kjartan Moe; Heidi E S Fjeldstad; Ralf Dechend; Anne Cathrine Staff

doi:10.1016/j.jri.2021.103331

Circulating HLA-G and its association with cardiovascular markers in pregnancy

J Reprod Immunol. 2021 Aug:146:103331. doi: 10.1016/j.jri.2021.103331. Epub 2021 May 19.

Authors

Tove Lekva¹, Daniel P Jacobsen², Meryam Sugulle², Kjartan Moe³, Heidi E S Fjeldstad⁴, Ralf Dechend⁵, Anne Cathrine Staff⁴

Affiliations

¹ Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: tove.lekva@ous-research.no.
² Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway.
³ Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway; Department of Obstetrics and Gynaecology, Bærum Hospital, Vestre Viken Hospital Trust, Norway.
⁴ Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.
⁵ Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin Berlin and Max-Delbruck Center for Molecular Medicine, Germany; Department of Cardiology and Nephrology, HELIOS-Klinikum, Berlin, Germany.

PMID: 34030048
DOI: 10.1016/j.jri.2021.103331

Abstract

Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation.

Keywords: CVD; Multiplex; Preeclampsia; SRC; VEGFD.

Publication types

Observational Study

MeSH terms

Biomarkers / blood
Case-Control Studies
Cell Differentiation / immunology
Cesarean Section
Female
HLA-G Antigens / blood*
HLA-G Antigens / immunology
Heart Disease Risk Factors
Humans
Pre-Eclampsia / blood
Pre-Eclampsia / diagnosis
Pre-Eclampsia / epidemiology*
Pre-Eclampsia / immunology
Pregnancy
Risk Assessment / methods
Trophoblasts / immunology*
Vascular Endothelial Growth Factor D / blood
src-Family Kinases / blood

Substances

Biomarkers
HLA-G Antigens
VEGFD protein, human
Vascular Endothelial Growth Factor D
src-Family Kinases