Chemical Synthesis of Triazole-Derived Suppressors of Strigolactone Functions

Methods Mol Biol. 2021:2309:25-30. doi: 10.1007/978-1-0716-1429-7_3.

Abstract

Triazole is a five-membered heteroring consists of two carbon atoms and three nitrogen atoms and exhibits a wide range of biological activities. The basic heterocyclic rings are 1,2,3-triazole and 1,2,4-triazole. Here we describe the chemical synthetic methods for triazole derivatives that can suppress the function of SL by inhibiting SL biosynthesis pathway or SL perception sites such as D14.

Keywords: Carotenoid cleavage dioxygenase; Cytochrome P450; Strigolactone; Strigolactone receptor; Triazole; α/β-Hydrolase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosynthetic Pathways / drug effects
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Heterocyclic Compounds, 3-Ring / antagonists & inhibitors*
  • Heterocyclic Compounds, 3-Ring / metabolism
  • Lactones / antagonists & inhibitors*
  • Lactones / metabolism
  • Molecular Structure
  • Plant Growth Regulators / chemical synthesis*
  • Plant Growth Regulators / pharmacology*
  • Plant Proteins / antagonists & inhibitors
  • Plant Proteins / metabolism
  • Receptors, Cell Surface / antagonists & inhibitors
  • Receptors, Cell Surface / metabolism
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis*
  • Triazoles / pharmacology*

Substances

  • Enzyme Inhibitors
  • GR24 strigolactone
  • Heterocyclic Compounds, 3-Ring
  • Lactones
  • Plant Growth Regulators
  • Plant Proteins
  • Receptors, Cell Surface
  • Triazoles