A noncovalent hybrid of [Pd(phen)(OAc)2] and st-DNA for the enantioselective hydroamination of β-nitrostyrene with methoxyamine

Mrityunjoy Pal; Dulal Musib; Maynak Pal; Gopal Rana; Gobinda Bag; Subrata Dutta; Mithun Roy

doi:10.1039/d1ob00714a

A noncovalent hybrid of [Pd(phen)(OAc)₂] and st-DNA for the enantioselective hydroamination of β-nitrostyrene with methoxyamine

Org Biomol Chem. 2021 Jun 16;19(23):5072-5076. doi: 10.1039/d1ob00714a.

Authors

Mrityunjoy Pal¹, Dulal Musib¹, Maynak Pal¹, Gopal Rana², Gobinda Bag¹, Subrata Dutta³, Mithun Roy¹

Affiliations

¹ Department of Chemistry, National Institute of Technology Manipur, Langol, 795004, Imphal, Manipur, India. mithunroy@nitmanipur.ac.in mithunroy.iisc@gmail.com.
² Department of Chemistry, Jadavpur University, Kolkata, 700032, West Bengal, India.
³ Department of Chemistry, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.

PMID: 34028485
DOI: 10.1039/d1ob00714a

Abstract

We developed a novel Pd-catalysed enantioselective synthesis of C-N bonds using the chiral scaffold of DNA. The non-covalently linked [Pd(phen)(OAc)2] with st-DNA catalysed the Markonicov hydroamination of β-nitrostyrene with methoxyamine for the first time with >75% enantiomeric excess (ee) in an aqueous buffer (pH 7.4) at room temperature.

Publication types

Research Support, Non-U.S. Gov't