At first functionalized graphene oxide was selected as a basic substrate obtained through process of functionalization of graphene oxide with diethylenetriamine as substrates. Then magnetic nanoparticle sediments were formed and coated on the functionalized graphene oxide as the core center. The core nanoparticle was added to a gel containing poly (lactic-co-glycolic acid), polyethylene glycol, and polyvinylpyrrolidone and nilotinib drug for forming a shell on the core. After separation and freeze-drying, single core-shell particles were obtained. The second shell was coated by dispersing first core-shell in a new gel containing polylactic acid, polyvinyl alcohol, polyethylene glycol, and nilotinib. The third layer was laminated on core-dual shell particle by entering in sodium alginate, polyethylene glycol, poly (lactic-co-glycolic acid), polylactic acid and nilotinib gel according to the same method used above. In order to determine the gradual release, the core-single, dual and triple shell nanoparticles dispersed in phosphate buffer saline at the several pHs (3, 5.4, 7.4) and as well as monitoring the released concentration of nilotinib by UV-Vis spectrophotometer technique. Core-triple shell particle had gradual release at three different rates over the long time. Finally, the average release rate for 400 mg of drug, in single layer, double-layer and three layers were reported to be equal to 15.8, 10.4 and 6.6 mg/h at intervals of 24, 37 and 60 h, respectively. The release rate of the drug reduced by increasing the pH value. All products were characterized using several techniques.
Keywords: Core-shell; Drug delivery; Gradual release; Graphene oxide; Magnetic; Nanotechnology; Nilotinib; Pharmaceutical chemistry.
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