The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

Poonam Kumari; Shahriar Tarighi; Thomas Braun; Alessandro Ianni

doi:10.1080/23723556.2021.1896349

The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

Mol Cell Oncol. 2021 Mar 31;8(3):1896349. doi: 10.1080/23723556.2021.1896349.

Authors

Poonam Kumari¹, Shahriar Tarighi¹, Thomas Braun¹, Alessandro Ianni¹

Affiliation

¹ Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.

Abstract

Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.

Keywords: SIRT7; nucleolus; nucleophosmin; p53; ultraviolet irradiation.

Grants and funding

This work was supported by the Deutsche Forschungsgemeinschaft [SFB1213 (TP A02 and B02) and SFB TRR81 TP A02];Max-Planck-Gesellschaft;Excellence Initiative “Cardiopulmonary Institute;German Center for Cardiovascular Research and European Research Area Network on Cardiovascular Diseases Project CLARIFY.;Klinische Forschungsgruppe [309 TP 08].